Phthalides
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Nom de la substance
Phthalides
Famille moléculaire
Composés phytochimiques classés dans les lactones
Source végétale
Propriétés
- Effet anti-inflammatoire
- Élimination de toxines telles que les cristaux d'acide urique
- Effet tranquillisant et d'amélioration du sommeil [1]
- Effet anti-hypertenseur par blocage des canaux calciques et relaxation artérielle, sans effet sur l'angiotensine [2]
- Le 3-n-butylphthalide protège de l'infiltration de la paroi artérielle par les neutrophiles lors du processus d'ischémie-reperfusion [3]
- Potentialités dans la maladie de Parkinson [4]
- Stimulation et/ou inhibition de nombreuses enzymes impliquées dans :
- L'hypertension artérielle et les troubles de la circulation, la production du NO (nitric oxide) [5]
- L'inhibition de tumeurs malignes
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Matsumoto K, Kohno S, Ojima K, Tezuka Y, Kadota S, Watanabe H. Effects of methylenechloride-soluble fraction of Japanese angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated mice. Life Sci 1998;62(23):2073-82. PMID 9627086
- ↑ D. Tsi and B. K. H. Tan. Cardiovascular Pharmacology of 3-n-butylphthalide in Spontaneously Hypertensive Rats. Phytotherapy Research, Vol. 11, 576—582 (1997)
- ↑ Xu HL, Feng YP. Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats. Acta Pharmacol Sin 2000 May;21(5):433-8. PMID 11324442
- ↑ Ru-Huei Fu, Horng-Jyh Harn, Shih-Ping Liu, Chang-Shi Chen, Wen-Lin Chang, Yue-Mi Chen, Jing-En Huang, Rong-Jhu Li, Sung-Yu Tsai, Huey-Shan Hung, Woei-Cherng Shyu, Shinn-Zong Lin, Yu-Chi Wang. n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease. PLoS One. 2014; 9(1): e85305. Published online 2014 January 8. doi: 10.1371/journal.pone.0085305 PMCID: PMC3885701 texte intégral
- ↑ Effects of 3-n-butylphthalide on production of vasoactive substances by cerebral and aortic endothelial cells. Xu HL, Feng YP. Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. PMID 11270994
- Matsuda H, Shimoda H, Yoshikawa M. Structure-requirements of isocoumarins, phthalides, and stilbenes from Hydrangeae Dulcis Folium for inhibitory activity on histamine release from rat peritoneal mast cells. Bioorg Med Chem 1999 Jul;7(7):1445-50. PMID 10465418
- Ko WC. A newly isolated antispasmodic--butylidenephthalide. Jpn J Pharmacol 1980 Feb;30(1):85-91. PMID 7401411
- Momin RA, Nair MG. Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds. Phytomedicine. 2002 May;9(4):312-8. PMID 12120812
- John J. Beck, Shen-Chieh Chou. The Structural Diversity of Phthalides from the Apiaceae. J. Nat. Prod., 2007, 70 (5), pp 891–900