Paradol

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Nom de la substance

Paradol et dérivés (paradols)

Famille moléculaire

Source végétale

Propriétés

  • Anticarcinogène, inducteur d’apoptose [1]
  • Anti-inflammatoire par inhibition de la cyclooxygénase-2 (COX-2) [2], [3]
  • Anti-agrégant, antalgique [4]
  • Atténue les douleurs de la neuropathie diabétique par affinité pour le récepteur vanilloïde TRPV-1 (2-paradol, 4-paradol, 6-paradol, 8-paradol, 10-paradol) [5]
  • Neuroprotecteur [6]
  • Antibactérien (6-paradol) sur Mycobactéries [7]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. ↑ Keum YS, Kim J, Lee KH, Park KK, Surh YJ, Lee JM, Lee SS, Yoon JH, Joo SY, Cha IH, Yook JI. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett. 2002 Mar 8;177(1):41-7. doi: 10.1016/s0304-3835(01)00781-9. PMID 11809529.
  2. ↑ Saptarini, N. M., Sitorus, E. Y., & Levita, J. (2013). Structure-based in silico study of 6-gingerol, 6-ghogaol, and 6-paradol, active compounds of ginger (Zingiber officinale) as COX-2 inhibitors. International Journal of Chemistry, 5(3), 12.
  3. ↑ Richard B. van Breemen, Yi Tao, Wenkui Li. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia, Volume 82, Issue 1, 2011, Pages 38-43, ISSN 0367-326X, https://doi.org/10.1016/j.fitote.2010.09.004.
  4. ↑ Gupta, R., Singh, P. K., Singh, R., & Singh, R. L. (2016). Pharmacological activities of Zingiber officinale (ginger) and its active ingredients: A review. International Journal of Innovation Science and Research, 4, 1-18.
  5. ↑ Fajrin, F. A., Rahmayanti, F., & Pratoko, D. K. (2020). The binding prediction of 6-paradol and its derivatives on TRPV1 agonist as a new compound for treating painful diabetic neuropathy. Jurnal ILMU DASAR, 21(2), 133-138.
  6. ↑ Gaire BP, Kwon OW, Park SH, Chun KH, Kim SY, Shin DY, Choi JW. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10(3):e0120203. doi: 10.1371/journal.pone.0120203. PMID 25789481; PMCID: PMC4366308.
  7. ↑ Ahmed M Galal (1996). Antimicrobial Activity of 6-Paradol and Related Compounds. International Journal of Pharmacognosy, 34:1, 64-69, DOI: 10.1076/phbi.34.1.64.13172
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