Agripaume

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Leonurus cardiaca
Leonurus sibiricus

Nom de la plante

Agripaume, cardiaque, motherwort (anglais)

Dénomination latine internationale

Leonurus cardiaca L.

Famille botanique

Lamiaceae

Description et habitat

  • Vivace présente dans presque toute l’Europe et en Asie, 60 à 150 cm, feuilles vert sombre à dessous blanchâtre, profondément découpées en lobes aigus, fleurs disposées en longs épis de glomérules
  • Calice à dents épineuses, longue corolle purpurine ou rose, +/- ponctuée, pubescente
  • Les 4 parties du fruit sont trigones et velues

Histoire et tradition

  • Son action sur le cœur et la circulation justifie son autre nom de cardiaque
  • Son nom vernaculaire anglais motherwort est justifié en raison de l'usage des plantes du genre Leonurus en gynécologie et néonatalogie [1]

Parties utilisées

  • Parties aériennes

Formes galéniques disponibles

  • Teinture-mère, teinture

Dosages usuels

Composition

Composants principaux de la plante

Composants principaux des bourgeons ou jeunes pousses

Composants principaux de l'huile essentielle

Propriétés

Propriétés de la plante

Propriétés du bourgeon

Propriétés de l'huile essentielle

Indications

Indications de la plante entière (phytothérapie)

  • Hypertension artérielle, surtout si elle s'accompagne d'anxiété et de troubles du sommeil [7]
  • Troubles neuro-végétatifs fonctionnels, troubles ménopausiques
  • Troubles cardiaques d’origine nerveuse
  • Asthme bronchique
  • Troubles accompagnant les aménorrhées
  • Tachycardies des hyperthyroïdies

Indications du bourgeon (gemmothérapie)

Indications spécifiques de l'huile essentielle (aromathérapie)

Mode d'action connu ou présumé

Formulations usuelles

Réglementation

Effets indésirables éventuels et précautions d'emploi

  • Bonne tolérance [26]
  • Contre-indiquée chez la femme enceinte

Références bibliographiques

  1. ↑ Zhang RH, Liu ZK, Yang DS, Zhang XJ, Sun HD, Xiao WL. Phytochemistry and pharmacology of the genus Leonurus: The herb to benefit the mothers and more. Phytochemistry. 2018 Mar;147:167-183. doi: 10.1016/j.phytochem.2017.12.016. Epub 2018 Jan 12. PMID 29335190.
  2. ↑ Miłkowska-Leyck K, Filipek B, Strzelecka H. Pharmacological effects of lavandulifolioside from Leonurus cardiaca. J Ethnopharmacol. 2002 Apr;80(1):85-90. PMID 11891090
  3. ↑ Ritter M, Melichar K, Strahler S, Kuchta K, Schulte J, Sartiani L, Cerbai E, Mugelli A, Mohr FW, Rauwald HW, Dhein S. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.). Planta Med. 2010 Apr;76(6):572-82. doi: 10.1055/s-0029-1240602. PMID 19918711
  4. ↑ Bernatoniene J, Kopustinskiene DM, Jakstas V, Majiene D, Baniene R, Kuršvietiene L, Masteikova R, Savickas A, Toleikis A, Trumbeckaite S. The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart. Planta Med. 2014 May;80(7):525-32. doi: 10.1055/s-0034-1368426. Epub 2014 May 19. PMID 24841965.
  5. ↑ Rong W, Li J, Pan D, Zhou Q, Zhang Y, Lu Q, Wang L, Wang A, Zhu Y, Zhu Q. Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver-Cardiac Crosstalk Metabolomics Study. Biomolecules. 2022 Oct 19;12(10):1512. doi: 10.3390/biom12101512. PMID 36291721; PMCID: PMC9599793.
  6. ↑ Rong W, Li J, Wang L, Luo S, Liang T, Qian X, Zhang X, Zhou Q, Zhu Y, Zhu Q. Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy. Front Cardiovasc Med. 2022 Aug 22;9:969553. doi: 10.3389/fcvm.2022.969553. PMID 36072867; PMCID: PMC9441747.
  7. ↑ 7,0 et 7,1 Shikov AN, Pozharitskaya ON, Makarov VG, Demchenko DV, Shikh EV. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res. 2011 Apr;25(4):540-3. doi: 10.1002/ptr.3292. PMID 20839214
  8. ↑ Zhu Q, Zhang J, Yang P, et al. Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry. The Scientific World Journal. 2014;2014:947946. doi:10.1155/2014/947946. texte intégral
  9. ↑ Rauwald, H. W., Savtschenko, A., Merten, A., Rusch, C., Appel, K., & Kuchta, K. (2015). GABAA receptor binding assays of standardized Leonurus cardiaca and Leonurus japonicus extracts as well as their isolated constituents. Planta Medica, 81(12/13), 1103-1110.
  10. ↑ Yang M, Yang S, Jin Z, Zhu S. Study on the biological assay of Herba Leonuri--analysis the dosage response curve of Herba Leonuri and oxytocin and establishment of adequate potency pattern. Zhong Yao Cai. 2002 Jun;25(6):409-11. PMID 12583332
  11. ↑ Lin JH, Lin QD, Liu XH, Yan JY, He J, Li L, Gu H, Sun LZ, Zhang JP, Yu S, Ma YY, Niu JM, Xia Y, Zhao SC, Li W, Wang HL, Wang BS. Multi-center study of motherwort injection to prevent postpartum hemorrhage after caesarian section. Zhonghua Fu Chan Ke Za Zhi. 2009 Mar;44(3):175-8. PMID 19570440
  12. ↑ Miao LL, Zhou QM, Peng C, Liu ZH, Xiong L. Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview. Biomed Pharmacother. 2019 Sep;117:109060. doi: 10.1016/j.biopha.2019.109060. Epub 2019 Jun 10. PMID 31195353.
  13. ↑ Xu D, Chen M, Ren X, Ren X, Wu Y. Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-κB signaling pathway. Fitoterapia. 2014 Sep;97:148-55. doi: 10.1016/j.fitote.2014.06.005. Epub 2014 Jun 9. PMID 24924288.
  14. ↑ Cheng H, Bo Y, Shen W, Tan J, Jia Z, Xu C, Li F. Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice. Int Immunopharmacol. 2015 Apr;25(2):406-15. doi: 10.1016/j.intimp.2015.02.023. PMID 25727888
  15. ↑ Liu C, Yin H, Gao J, Xu X, Zhang T, Yang Z. Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. Phytomedicine. 2016 Dec 1;23(13):1638-1646. doi: 10.1016/j.phymed.2016.10.005. Epub 2016 Oct 8. PMID 27823628.
  16. ↑ Li J, Zhang S, Liu X, Han D, Xu J, Ma Y. Neuroprotective effects of leonurine against oxygen-glucose deprivation by targeting Cx36/CaMKII in PC12 cells. PLoS One. 2018 Jul 17;13(7):e0200705. doi: 10.1371/journal.pone.0200705. PMID 30016355; PMCID: PMC6049927.
  17. ↑ Jafari, S., Moradi, A., Salaritabar, A., Hadjiakhoondi, A., & Khanavi, M. (2010). Determination of total phenolic and flavonoid contents of Leonurus cardiaca L. in compare with antioxidant activity. Research Journal of Biological Sciences, 5(7), 484-487.
  18. ↑ Sadowska, B., Micota, B., Różalski, M., Redzynia, M., & Różalski, M. (2017). The immunomodulatory potential of Leonurus cardiaca extract in relation to endothelial cells and platelets. Innate Immunity, 23(3), 285-295.
  19. ↑ Wojtyniak K, Szymański M, Matławska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2013 Aug;27(8):1115-20. doi: 10.1002/ptr.4850. PMID 23042598
  20. ↑ Schmidt S, Jakab M, Jav S, Streif D, Pitschmann A, Zehl M, Purevsuren S, Glasl S, Ritter M. Extracts from Leonurus sibiricus L. increase insulin secretion and proliferation of rat INS-1E insulinoma cells. J Ethnopharmacol. 2013 Oct 28;150(1):85-94. doi: 10.1016/j.jep.2013.08.013. PMID 23978659.
  21. ↑ Liang H, Liu P, Wang Y, Song S, Ji A. Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. Phytomedicine. 2011 Jul 15;18(10):811-8. doi: 10.1016/j.phymed.2011.01.020. PMID 21377850.
  22. ↑ European Medicine Agency EMA/HMPC/127430/2010, Committee on Herbal Medicinal Products (HMPC). Assessment report on Leonurus cardiaca L., herba. 6 May 2010
  23. ↑ Pitschmann A, Waschulin C, Sykora C, Purevsuren S, Glasl S. Microscopic and Phytochemical Comparison of the Three Leonurus Species L. cardiaca, L. japonicus, and L. sibiricus. Planta Med. 2017 Oct;83(14-15):1233-1241. doi: 10.1055/s-0043-118034. Epub 2017 Aug 24. PMID 28837995.
  24. ↑ Kuchta K, Volk RB, Rauwald HW. Stachydrine in Leonurus cardiaca, Leonurus japonicus, Leonotis leonurus: detection and quantification by instrumental HPTLC and 1H-qNMR analyses. Pharmazie. 2013 Jul;68(7):534-40. PMID 23923634
  25. ↑ Kuchta K, Ortwein J, Rauwald HW. Leonurus japonicus, Leonurus cardiaca, Leonotis leonurus: a novel HPLC study on the occurrence and content of the pharmacologically active guanidino derivative leonurine. Pharmazie. 2012 Dec;67(12):973-9. PMID 23346757
  26. ↑ Han SR, Han HY, Lee BS, Min BS, Chung MK, Young Jeong J, Roh HS, Seok JH, Kim SK. Toxicity assessment of Leonuri Herba aqueous extract orally administered to rats for 13 consecutive weeks. J Ethnopharmacol. 2013 Aug 26;149(1):371-6. doi: 10.1016/j.jep.2013.06.053. PMID 23834914
  • Fierascu RC, Fierascu I, Ortan A, Fierascu IC, Anuta V, Velescu BS, Pituru SM, Dinu-Pirvu CE. Leonurus cardiaca L. as a Source of Bioactive Compounds: An Update of the European Medicines Agency Assessment Report (2010). Biomed Res Int. 2019 Apr 17;2019:4303215. doi: 10.1155/2019/4303215. PMID 31119169; PMCID: PMC6500680.
  • Liu XH, Pan LL, Zhu YZ. Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):274-82. doi: 10.1111/j.1440-1681.2011.05630.x. PMID 22004449
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