Santamarine
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Nom de la substance
Santamarine
Famille moléculaire
Source végétale
Propriétés
- Antispasmodique des muscles lisses par effet alphabloquant, inhibe les contractions induites par la sérotonine et la phényléphrine (agoniste α1-adrénergique) [1]
- Anti-inflammatoire [2], [3]
- Antitumoral [4]
- Cytotoxique vis-à-vis de certaines lignées tumorales (carcinome pulmonaire GLC4, cancer colorectal COLO320) [5]
- Antimicrobien, inhibition du quorum sensing bactérien [6]
- Antimycobactérien (potentialités dans la tuberculose ?) [7]
- Anti-inflammatoire, inhibition de la production de TNF-alpha (tumor necrosis factor-alpha) [8]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Alejandra Orona-Ortiz, Leticia García-de la Cruz, Israel González-Soto, Liana Medina-Cruz, José Luis Balderas López, José Carlos Tavares Carvalho, Andrés Navarrete. Inhibition of phenylephrine- or serotonin-induced rat aorta contractions by mexican feverfew (Tanacetum parthenium (L.) Schultz-Bip). Latinoamericana de Quimica, Vol 46 No 2-3 (2018)
- ↑ Choi HG, Lee DS, Li B, Choi YH, Lee SH, Kim YC. Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. Int Immunopharmacol. 2012 Jul;13(3):271-9. doi: 10.1016/j.intimp.2012.04.016. PMID 22564506
- ↑ Al-Attas AA, El-Shaer NS, Mohamed GA, Ibrahim SR, Esmat A. Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes. J Ethnopharmacol. 2015 Dec 24;176:365-74. doi: 10.1016/j.jep.2015.11.026. PMID 26593213
- ↑ Li Y, Ni ZY, Zhu MC, Dong M, Wang SM, Shi QW, Zhang ML, Wang YF, Huo CH, Kiyota H, Cong B. Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica. Z Naturforsch C J Biosci. 2012 Jul-Aug;67(7-8):375-80. PMID 23016276
- ↑ Gören N, Woerdenbag HJ, Bozok-Johansson C. Cytotoxic and antibacterial activities of sesquiterpene lactones isolated from Tanacetum praeteritum subsp. praeteritum. Planta Med. 1996 Oct;62(5):419-22. PMID 8923806
- ↑ Ibrahim SRM, Ahmed El-Shaer NSA, Asfour HZ, Elshali KZ, Awad Shaaban MI, Al-Attas AAM, Allah Mohamed GA. Antimicrobial, antiquorum sensing, and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes. Pak J Pharm Sci. 2019 Jan;32(1):109-115. PMID 30772798
- ↑ Coronado-Aceves EW, Velázquez C, Robles-Zepeda RE, Jiménez-Estrada M, Hernández-Martínez J, Gálvez-Ruiz JC, Garibay-Escobar A. Reynosin and santamarine: two sesquiterpene lactones from Ambrosia confertiflora with bactericidal activity against clinical strains of Mycobacterium tuberculosis. Pharm Biol. 2016 Nov;54(11):2623-2628. PMID 27180996
- ↑ Cho JY, Park J, Yoo ES, Baik KU, Jung JH, Lee J, Park MH. Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells. Planta Med. 1998 Oct;64(7):594-7. PMID 9810262