Reynosine

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Nom de la substance

Reynosine

Famille moléculaire

Lactone sesquiterpénique

Source végétale

Propriétés

  • Antimicrobien, inhibition du quorum sensing bactérien [2]
  • Antimycobactérien (potentialités dans la tuberculose ?) [3]
  • Anti-inflammatoire [4], inhibition de la production de TNF-alpha (tumor necrosis factor-alpha) [5]
  • Cytotoxique vis-à-vis de certaines lignées tumorales (carcinome pulmonaire GLC4, cancer colorectal COLO320) [6]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. El-Feraly FS, Chan YM. Isolation and characterization of the sesquiterpene lactones costunolide, parthenolide, costunolide diepoxide, santamarine, and reynosin from Magnolia grandiflora L. J Pharm Sci. 1978 Mar;67(3):347-50. PMID 641720
  2. Ibrahim SRM, Ahmed El-Shaer NSA, Asfour HZ, Elshali KZ, Awad Shaaban MI, Al-Attas AAM, Allah Mohamed GA. Antimicrobial, antiquorum sensing, and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes. Pak J Pharm Sci. 2019 Jan;32(1):109-115. PMID 30772798
  3. Coronado-Aceves EW, Velázquez C, Robles-Zepeda RE, Jiménez-Estrada M, Hernández-Martínez J, Gálvez-Ruiz JC, Garibay-Escobar A. Reynosin and santamarine: two sesquiterpene lactones from Ambrosia confertiflora with bactericidal activity against clinical strains of Mycobacterium tuberculosis. Pharm Biol. 2016 Nov;54(11):2623-2628. PMID 27180996
  4. Al-Attas AA, El-Shaer NS, Mohamed GA, Ibrahim SR, Esmat A. Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes. J Ethnopharmacol. 2015 Dec 24;176:365-74. doi: 10.1016/j.jep.2015.11.026. PMID 26593213
  5. Cho JY, Park J, Yoo ES, Baik KU, Jung JH, Lee J, Park MH. Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells. Planta Med. 1998 Oct;64(7):594-7. PMID 9810262
  6. Gören N, Woerdenbag HJ, Bozok-Johansson C. Cytotoxic and antibacterial activities of sesquiterpene lactones isolated from Tanacetum praeteritum subsp. praeteritum. Planta Med. 1996 Oct;62(5):419-22. PMID 8923806