Nimbolide
Aller à la navigation
Aller à la recherche
Nom de la substance
Nimbolide
Famille moléculaire
Lactone triterpénique, limonoïde
Source végétale
- Fleurs de neem (Azadirachta indica)
Propriétés
- Activité antipaludéenne
- Activité anticancer, promoteur d’apoptose de cellules cancéreuses, activité antiproliférative vi-à-vis de nombreuses lignées cellulaires de cancer [1], cancer du colon [2], cancer du sein [3], cancer du col utérin [4]
- Inhibition de la croissance de cellules de cancer du pancréas [5]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Roy MK, Kobori M, Takenaka M, Nakahara K, Shinmoto H, Isobe S, Tsushida T. Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica). Phytother Res. 2007 Mar;21(3):245-50. PMID 17163581
- ↑ Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M, Aggarwal BB. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. J Biol Chem. 2011 Jan 14;286(2):1134-46. doi: 10.1074/jbc.M110.191379. PMID 21078664
- ↑ Elumalai P1, Gunadharini DN, Senthilkumar K, Banudevi S, Arunkumar R, Benson CS, Sharmila G, Arunakaran J. Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway. Toxicol Lett. 2012 Nov 30;215(2):131-42. doi: 10.1016/j.toxlet.2012.10.008. PMID 23089555
- ↑ Priyadarsini RV, Murugan RS, Sripriya P, Karunagaran D, Nagini S. The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells. Free Radic Res. 2010 Jun;44(6):624-34. doi: 10.3109/10715761003692503. PMID 20429769
- ↑ Ramadevi Subramani, Elizabeth Gonzalez, Arunkumar Arumugam, Sushmita Nandy, Viviana Gonzalez, Joshua Medel, Fernando Camacho, Andrew Ortega, Sandrine Bonkoungou, Mahesh Narayan, Alok kumar Dwivedi & Rajkumar Lakshmanaswamy. Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition. Scientific Reports 6, Article number: 19819 (2016) doi:10.1038/srep19819