Myricitroside

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Nom de la substance

Myricitroside, myricitrine, myricétine-3-O-rhamnose, myricétine-3-O-α-L-rhamnopyranoside (dérivé de la myricétine)

Famille moléculaire

Flavonoïde

Source végétale

Propriétés

  • Antalgique [1], [2], anti-nociceptive, diminue les douleurs neuropathiques [3], même en présence de glutamate, substance P, capsaïcine, interleukine 1 béta (IL-1béta) et tumor necrosis factor-alpha (TNF-alpha)
  • Activité antipsychotique [4]
  • Anti-inflammatoire
  • Inhibiteur des MPP-2 (matrix métalloprotéinases 2) [5], facteur clé dans l'apparition de métastases de cancer du colon
  • Inhibe la thyroperoxydase [6]

Effet thérapeutique

Effets indésirables

Bibliographie

  • Ko, C.H., Shen, S.C., Hsu, C.S., Chen, Y.C. Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochem. Pharmacol. (2005) [1]
  • Shimizu, R., Shimabayashi, H., Moriwaki, M. Enzymatic Production of Highly Soluble Myricitrin Glycosides Using beta-Galactosidase. Biosci. Biotechnol. Biochem. (2006)
  • Lee, S.Y., Min, B.S., Kim, J.H., Lee, J., Kim, T.J., Kim, C.S., Kim, Y.H., Lee, H.K. Flavonoids from the leaves of Litsea japonica and their anti-complement activity. Phytotherapy research : PTR. (2005) [2]
  • Yokomizo, A., Moriwaki, M. Transepithelial permeability of myricitrin and its degradation by simulated digestion in human intestinal Caco-2 cell monolayer. Biosci. Biotechnol. Biochem. (2005)
  • Complément de bibliographie sur [3]
  1. ↑ Meotti FC, Fachinetto R, Maffi LC, Missau FC, Pizzolatti MG, Rocha JB, Santos AR. Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels. Eur J Pharmacol. 2007 Jul 19;567(3):198-205. PMID 17467689
  2. ↑ Meotti, F.C., Luiz, A.P., Pizzolatti, M.G., Kassuya, C.A., Calixto, J.B., Santos, A.R. Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. J. Pharmacol. Exp. Ther. (2006) [4]
  3. ↑ Meotti, F.C., Missau, F.C., Ferreira, J., Pizzolatti, M.G., Mizuzaki, C., Nogueira, C.W., Santos, A.R. Anti-allodynic property of flavonoid myricitrin in models of persistent inflammatory and neuropathic pain in mice. Biochem. Pharmacol. (2006) [5]
  4. ↑ Pereira, M; Siba, IP; Chioca, LR; Correia, D; Vital, MA; Pizzolatti, MG; Santos, AR; Andreatini, R (August 2011). "Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 35(7): 1636–44. doi:10.1016/j.pnpbp.2011.06.002. PMID 21689712.
  5. ↑ Ko, C.H., Shen, S.C., Lee, T.J., Chen, Y.C. Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. Mol. Cancer Ther. (2005). PMID 15713899
  6. ↑ Ferreira, A.C., Neto, J.C., da Silva, A.C., Kuster, R.M., Carvalho, D.P. Inhibition of thyroid peroxidase by Myrcia uniflora flavonoids. Chem. Res. Toxicol. (2006). PMID 16544938
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