Leptospermone

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Nom de la substance

Leptospermone, 2,2,4,4-Tetramethyl-6-(3-methylbutanoyl)cyclohexane-1,3,5-trione

Famille moléculaire

Source végétale

Propriétés

  • Antibactérienne sur germes anaérobies, inhibe la croissance de Clostridium difficile et Clostridium perfringens [1]
  • Potentialise les HE de tea tree et de niaouli dans les infections à Staphylococcus aureus et Moraxella catarrhalis [2]
  • Herbicide [3], [4], surtout par un dérivé, la mésotrione [5]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Eun-Young Jeong, Ju-Hyun Jeon, Hyung-Wook Kim, Min-Gi Kim, Hoi-Seon Lee. Antimicrobial activity of leptospermone and its derivatives against human intestinal bacteria. Food Chemistry, Volume 115, Issue 4, 15 August 2009, Pages 1401-1404 [1]
  2. Christoph F, Kaulfers PM, Stahl-Biskup E. In vitro evaluation of the antibacterial activity of beta-triketones admixed to Melaleuca oils. Planta Med. 2001 Nov;67(8):768-71. PMID 11731927
  3. Romdhane S, Devers-Lamrani M, Barthelmebs L, et al. Ecotoxicological Impact of the Bioherbicide Leptospermone on the Microbial Community of Two Arable Soils. Frontiers in Microbiology. 2016;7:775. doi:10.3389/fmicb.2016.00775. texte intégral
  4. Dumas E, Giraudo M, Goujon E, Halma M, Knhili E, Stauffert M, Batisson I, Besse-Hoggan P, Bohatier J, Bouchard P, Celle-Jeanton H, Costa Gomes M, Delbac F, Forano C, Goupil P, Guix N, Husson P, Ledoigt G, Mallet C, Mousty C, Prévot V, Richard C, Sarraute S. Fate and ecotoxicological impact of new generation herbicides from the triketone family: An overview to assess the environmental risks. J Hazard Mater. 2017 Mar 5;325:136-156. doi: 10.1016/j.jhazmat.2016.11.059. PMID 27930998
  5. Derek Cornes. Callisto: a very successful maize herbicide inspired by allelochemistry. Allelopathy [2]
  • Hellyer RO. The occurrence of some beta-triketones in the steam-volatile oils of some myrtaceous Australian plants Australian Journal of Chemistry, 1968, 21: 2825-2828.