Asiaticoside
Aller à la navigation
Aller à la recherche
Nom de la substance
Asiaticoside
Famille moléculaire
Saponoside triterpénique
Source végétale
Propriétés
- Vulnéraire [1]
- Stimulant de la biosynthèse du collagène [2]
- Neuroprotection vis-à-vis des maladies neurodégénératives et surtout de la maladie de Parkinson [3], [4], [5], [6]
- Protection vis-à-vis de la protéine béta-amyloïde [7], [8]
Effet thérapeutique
- Cicatrisation des plaies
- Insuffisance veineuse, plaies variqueuses
- Maladie d'Alzheimer (?)
Effets indésirables
Bibliographie
- ↑ Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol. 1999 Apr;65(1):1-11. PMID 10350364
- ↑ Lee J, Jung E, Kim Y, Park J, Park J, Hong S, Kim J, Hyun C, Kim YS, Park D. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling. Planta Med. 2006 Mar;72(4):324-8. PMID 16557473
- ↑ Haleagrahara N, Ponnusamy K. Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats. J Toxicol Sci. 2010 Feb;35(1):41-7. PMID 20118623
- ↑ Xu CL, Qu R, Zhang J, Li LF, Ma SP. Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats. Fitoterapia. 2013 Oct;90:112-8. doi: 10.1016/j.fitote.2013.07.009. PMID 23876367
- ↑ Xu CL, Wang QZ, Sun LM, Li XM, Deng JM, Li LF, Zhang J, Xu R, Ma SP. Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax. Pharmacol Biochem Behav. 2012 Jan; 100(3):413-8. PMID 22001429
- ↑ Subathra M, Shila S, Devi MA, Panneerselvam C. Emerging role of Centella asiatica in improving age-related neurological antioxidant status. Exp Gerontol. 2005 Aug-Sep;40(8-9):707-15. PMID 16026958
- ↑ Mook-Jung I, Shin JE, Yun SH, Huh K, Koh JY, Park HK, Jew SS, Jung MW. Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. J Neurosci Res. 1999 Nov 1;58(3):417-25. PMID 10518115
- ↑ Hossain S, Hashimoto M, Katakura M, Al Mamun A, Shido O. Medicinal value of asiaticoside for Alzheimer's disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking. BMC Complementary and Alternative Medicine 2015, 15:118 (14 April 2015) Abstract texte intégral